Reach Perugia by car:
- From the north (Milan, Florence), exit Valdichiana, where the SS75bis motorway, entering Umbria at Lake Trasimeno and continuing until Perugia.
- From the South (Rome), via the A1 motorway, the best exit to reach the regional capital is Orte, which is connected to first follow SS204 (toward Terni) first, and the E45 (or SS3bis), from Terni to Perugia
- Driving along the A14 on the Adriatic coast, the best way to reach Perugia is to leave the motorway at Cesena, then, via the E45 reach before Citta di Castello, then Perugia.
The SS75bis around as an open ring Perugia, and has 5 outputs for the city, which, in North-South direction, are: Perugia Ferro di Cavallo, Perugia Madonna Alta, Perugia San Faustino, Perugia and Perugia Prepo Piscille.
Reach Perugia by train:
- Coming from the north, on the Florence-Rome, get off at Terontola, situated on the sideline Lake Trasimeno, Perugia, Assisi, Spello, Foligno. So coming from Florence take a train that daily colegano the Tuscan city to Terontola / Cortona (about 1 hour and a half walk) then the station Terontala take one of the trains that connect to Perugia (35-50 minutes diu percorenza).
- Coming from the south on the main Rome-Ancona stop at Foligno located on the secondary line Spello, Assisi, Perugia, Lake Trasimeno. So provendnedo from Rome, take one of the daily trains that connect the capital to Ancona and get off at Foligno (about 2 hours walk). From Foligno take one of the local trains that colegano in Perugia (30-35 minute trip).